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Heparan sulfate in chronic kidney diseases: exploring the role of 3-O-sulfation

Lookup NU author(s): Laura Ferreras, Dr Anna Moles Fernandez, Dr Aldi Situmorang, Imogen Wilson, Katie Cooke, Professor Neil SheerinORCiD, Professor Simi Ali

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Abstract

One of the main feature of chronic kidney disease is the development of renal fibrosis. Heparan Sulfate (HS) is involved in disease development by modifying the function of growth factors and cytokines and creating chemokine gradients. In this context, we aimed to understand the function of HS sulfation in renal fibrosis. Using a mouse model of renal fibrosis, we found that total HS 2-O-sulfation was increased in damaged kidneys, whilst, tubular staining of HS 3-O-sulfation was decreased. The expression of HS modifying enzymes significantly correlated with the development of fibrosis with HS3ST1 demonstrating the strongest correlation. The pro-fibrotic factors TGF2/IL1

Publication metadata

Author(s): Ferreras L, Moles A, Situmorang G, el Masri R, Wilson I, Cooke K, Thompson E, Kusche-Gullberg M, Vivès M, Sheerin N, Ali S

Publication type: Article

Publication status: Published

Journal: Biochimica et Biophysica Acta (BBA) - General Subjects

Year: 2019

Volume: 1863

Issue: 5

Pages: 839-848

Print publication date: 01/05/2019

Online publication date: 19/02/2019

Acceptance date: 16/02/2019

Date deposited: 16/02/2019

ISSN (print): 0304-4165

ISSN (electronic): 1872-8006

Publisher: Elsevier BV

URL: https://doi.org/10.1016/j.bbagen.2019.02.009

DOI: 10.1016/j.bbagen.2019.02.009

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