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Drug delivery systems for programmed and on-demand release

Lookup NU author(s): Dr Cindy LeeORCiD


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With the advancement in medical science and understanding the importance of biodistribution and pharmacokineticsof therapeutic agents, modern drug delivery research strives to utilize novel materials and fabricationtechnologies for the preparation of robust drug delivery systems to combat acute and chronic diseases. Comparedto traditional drug carriers, which could only control the release of the agents in a monotonic manner, the newdrug carriers are able to provide a precise control over the release time and the quantity of drug introducedinto the patient's body. To achieve this goal, scientists have introduced “programmed” and “on-demand” approaches.The former provides delivery systems with a sophisticated architecture to precisely tune the releaserate for a definite time period, while the latter includes systems directly controlled by an operator/practitioner,perhaps with a remote device triggering/affecting the implanted or injected drug carrier. Ideally, such devicescan determine flexible release pattern and intensify the efficacy of a therapy via controlling time, duration, dosage,and location of drug release in a predictable, repeatable, and reliablemanner. This review sheds light on thepast and current techniques available for fabricating and remotely controlling drug delivery systems and addressesthe application of new technologies (e.g. 3D printing) in this field.

Publication metadata

Author(s): Davoodi P, Lee LY, Xu Q, Sunil V, Sun Y, Soh S, Wang CH

Publication type: Article

Publication status: Published

Journal: Advanced Drug Delivery Reviews

Year: 2018

Volume: 132

Pages: 104-138

Print publication date: 01/07/2018

Online publication date: 06/07/2018

Acceptance date: 02/07/2018

ISSN (print): 0169-409X

ISSN (electronic): 1872-8294

Publisher: Elsevier


DOI: 10.1016/j.addr.2018.07.002


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