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Nutrition and Ageing

Lookup NU author(s): Dr Fiona MalcomsonORCiD, Professor John Mathers


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The ageing trajectory is plastic and can be slowed down by lifestyle factors, including good nutrition, adequate physical activity and avoidance of smoking. In humans, plant-based diets such as the Mediterranean dietary pattern are associated with healthier ageing and lower risk of age-related disease, whereas obesity accelerates ageing and increases the likelihood of most common complex diseases including CVD, T2D, dementia, musculoskeletal diseases and several cancers. As yet, there is only weak evidence in humans about the molecular mechanisms through which dietary factors modulate ageing but evidence from cell systems and animal models suggest that it is probable that better dietary choices influence all 9 hallmarks of ageing. It seems likely that better eating patterns retard ageing in at least two ways including (i) by reducing pervasive damaging processes such as inflammation, oxidative stress/redox changes and metabolic stress and (ii) by enhancing cellular capacities for damage management and repair. From a societal perspective, there is an urgent imperative to discover, and to implement, cost-effective lifestyle (especially dietary) interventions which enable each of us to age well, i.e. to remain physically and socially active and independent and to minimise the period towards the end of life when individuals suffer from frailty and multi-morbidity.

Publication metadata

Author(s): Malcomson FC, Mathers JC

Editor(s): J. Robin Harris and Viktor I. Korolchuk

Publication type: Book Chapter

Publication status: Published

Book Title: Biochemistry and Cell Biology of Ageing: Part I Biomedical Science

Year: 2018

Volume: 90

Pages: 373-424

Online publication date: 19/02/2019

Acceptance date: 02/04/2018

Series Title: Subcellular Biochemistry

Publisher: Springer

Place Published: Singapore


DOI: 10.1007/978-981-13-2835-0_13

PubMed id: 30779016

Library holdings: Search Newcastle University Library for this item

ISBN: 9789811328343