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Nanocomposite Microneedle Electrochemical Arrays for Non-Invasive Transdermal Sensing of Analytes

Lookup NU author(s): Dr Keng Wooi Ng

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Abstract

Microneedle Arrays are defined as devices with needle-like projections with lengths typically up to 1mm and diameter in the order of microns. They are minimally invasive and simplistic devices, foreseeing a progressive divergence from the field of drug delivery and vaccination into the realm of diagnostic and/or point-of-care (POC) devices. Such systems are highly relevant for, (1) diseases that require frequent monitoring such as diabetes, (2) rapid diagnosis of infectious diseases e.g. Dengue Fever and (3) for differential diagnosis of complex diseases. Recent developments in microneedle (MN) based POC systems have seen the emergence of in vivo biosensing MN’s that would enable real time and continuous detection of physiologically relevant molecules such as dopamine, uric acid and nitric oxide. However, progress in this area is limited by multi-step processing and lengthy fabrication times. Thus, we showcase micromoulding as a facile fabrication strategy for developing Carbon-Nanotube/Poly (lactic) acid composite MNs; emphasizing the fabrication steps involved and their influence on MN electrochemical behavior. Mechanical assessment of the MNs have shown the axial load and sheer failure forces to be strong enough to withstand resistive forces during skin insertion. Electrochemical characterization of these MNs have demonstrated their ability to sample physiologically relevant molecules such as ascorbic acid at low concentrations. We further report on the ability of these MNs to sample from complex tissue environments.


Publication metadata

Author(s): Skaria E, Flint MS, Patel BA, Ng KW

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: PittCon

Year of Conference: 2017

Acceptance date: 09/12/2016

URL: https://ca.pittcon.org/Technical%20Program/tpabstra17.nsf/focus/9A21346332846E818525800D007BA814?opendocument


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