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Lookup NU author(s): Dr Mustafa Sevinc, Susan Stamp, David Talbot, Professor Neil SheerinORCiD
This is the authors' accepted manuscript of an article that has been published in its final definitive form by Elsevier Inc., 2019.
For re-use rights please refer to the publisher's terms and conditions.
AbstractMain ProblemHypothermic machine perfusion is used to improve renal perfusion and reduce the rate of early and late graft dysfunction. It has been used in our unit since 2001. It has two modes of flow: continuous or pulsatile. The aim of this study is to compare the modes of perfusion in terms of perfusion-related parameters, graft survival and estimated glomerular filtration rate. MethodsAll donation after cardiac death kidneys between 2002 and 2014 were reviewed. Sixty four pairs of kidneys were identified of which one kidney underwent pulsatile and the other continuous perfusion. Machine parameters including resistance and perfusion flow index levels at 0, 1, 2, 3, 4 hours were recorded and glutathione S-transferase measured in perfusate. Estimated glomerular filtration rate from the 1st week of transplantation until 5th year and graft survival rates were determined. ResultsMachine parameters were similar at all time points. Estimated glomerular filtration rates and graft survival were the same irrespective of perfusion mode.ConclusionPulsatile perfusion may beregarded as more physiological. However, we could not identify difference in outcome following transplantation of kidneys from the same donor that had been perfused under pulsatile or continuous conditions.
Author(s): Sevinc M, Stamp S, Ling J, Carter N, Talbot D, Sheerin NS
Publication type: Article
Publication status: Published
Journal: Transplantation Proceedings
Year: 2019
Volume: 51
Issue: 6
Pages: 1785-1790
Print publication date: 01/07/2019
Online publication date: 06/08/2019
Acceptance date: 12/03/2019
Date deposited: 13/03/2019
ISSN (print): 0041-1345
ISSN (electronic): 1873-2623
Publisher: Elsevier Inc.
URL: https://doi.org/10.1016/j.transproceed.2019.03.025
DOI: 10.1016/j.transproceed.2019.03.025
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