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Diaxial Diureido Decalins as Compact, Efficient and Tunable Anion Transporters

Lookup NU author(s): Dr Luke Judd

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Abstract

Decalins bearing two axial -NHCONHAr substituents and an ester-linked alkyl side chain have been synthesized and studied as anion receptors and transporters. The design relates to steroid-based "cholapods" but is more compact and less intrinsically lipophilic. Transport rates depend on both NHAr and the alkyl side chain. High activities can be achieved; with optimal substitution, chloride-nitrate exchange across vesicle membranes is measurable at transporter/lipid ratios as low as 1:250000.

Publication metadata

Author(s): Hussain S, Brotherhood PR, Judd LW, Davis AP

Publication type: Article

Publication status: Published

Journal: Journal of the American Chemical Society

Year: 2011

Volume: 133

Issue: 6

Pages: 1614-1617

Print publication date: 16/02/2011

Online publication date: 21/01/2011

Acceptance date: 23/08/2010

ISSN (print): 0002-7863

ISSN (electronic): 1520-5126

Publisher: American Chemical Society

URL: https://doi.org/10.1021/ja1076102

DOI: 10.1021/ja1076102

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