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Magnetic-Silk Core-Shell Nanoparticles as Potential Carriers for Targeted Delivery of Curcumin into Human Breast Cancer Cells

Lookup NU author(s): Professor Catherine BiggsORCiD

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Abstract

Curcumin is a promising anticancer drug but itsapplications in cancer therapy are limited due to its poorsolubility, short half-life, and low bioavailability. In this article,we present a curcumin loaded magnetic silk fibroin core−shellnanoparticle system for sustained release of curcumin intobreast cancer cells. Curcumin loaded magnetic silk fibroincore−shell nanoparticles were fabricated by a simple saltingoutmethod using sodium phosphate with magnetic nanoparticles.The size, zeta potential, encapsulation/loadingefficiency, and curcumin release rate were controlled andoptimized by regulating silk fibroin concentration, pH value ofthe phosphate solution, and curcumin usage. Curcumin loadedmagnetic silk fibroin core−shell nanoparticles showedenhanced cytotoxicity and higher cellular uptake in the human Caucasian breast adenocarcinoma cell line (MDA-MB-231cells) evidenced by MTT and cellular uptake assays. In addition, silk fibroin nanoparticles and magnetic silk fibroinnanoparticles without curcumin loaded were used as controls. The particles prepared using sodium phosphate showedsignificantly smaller diameter (90−350 nm) compared with those prepared using potassium phosphate, which possess a diameterrange of 500−1200 nm. These smaller particles are superior for biomedical applications since such a size range is particularlydesired for cell internalization. In addition, the magnetic cores inside the particles provide the possibility of using an externalmagnet for cancer targeting.

Publication metadata

Author(s): Song WX, Muthana M, Mukherjee J, Falconer RJ, Biggs CA, Zhao XB

Publication type: Article

Publication status: Published

Journal: ACS Biomaterials Science and Engineering

Year: 2017

Volume: 3

Issue: 6

Pages: 1027-1038

Online publication date: 03/05/2017

Acceptance date: 03/05/2017

ISSN (electronic): 2373-9878

Publisher: American Chemical Society

URL: https://doi.org/10.1021/acsbiomaterials.7b00153

DOI: 10.1021/acsbiomaterials.7b00153

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