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Lookup NU author(s): Professor Catherine Biggs
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Curcumin is a promising anticancer drug but itsapplications in cancer therapy are limited due to its poorsolubility, short half-life, and low bioavailability. In this article,we present a curcumin loaded magnetic silk fibroin core−shellnanoparticle system for sustained release of curcumin intobreast cancer cells. Curcumin loaded magnetic silk fibroincore−shell nanoparticles were fabricated by a simple saltingoutmethod using sodium phosphate with magnetic nanoparticles.The size, zeta potential, encapsulation/loadingefficiency, and curcumin release rate were controlled andoptimized by regulating silk fibroin concentration, pH value ofthe phosphate solution, and curcumin usage. Curcumin loadedmagnetic silk fibroin core−shell nanoparticles showedenhanced cytotoxicity and higher cellular uptake in the human Caucasian breast adenocarcinoma cell line (MDA-MB-231cells) evidenced by MTT and cellular uptake assays. In addition, silk fibroin nanoparticles and magnetic silk fibroinnanoparticles without curcumin loaded were used as controls. The particles prepared using sodium phosphate showedsignificantly smaller diameter (90−350 nm) compared with those prepared using potassium phosphate, which possess a diameterrange of 500−1200 nm. These smaller particles are superior for biomedical applications since such a size range is particularlydesired for cell internalization. In addition, the magnetic cores inside the particles provide the possibility of using an externalmagnet for cancer targeting.
Author(s): Song WX, Muthana M, Mukherjee J, Falconer RJ, Biggs CA, Zhao XB
Publication type: Article
Publication status: Published
Journal: ACS Biomaterials Science and Engineering
Online publication date: 03/05/2017
Acceptance date: 03/05/2017
ISSN (electronic): 2373-9878
Publisher: American Chemical Society
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