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Bones and muscular dystrophies: what do we know?

Lookup NU author(s): Dr Claire Wood, Professor Volker Straub

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Abstract

PURPOSE OF REVIEW: Muscle and bone are intrinsically linked, and therefore, it is not surprising that many muscular dystrophies are associated with impaired bone health and increased risk of osteoporosis. Osteoporotic fracture is an important and preventable cause of morbidity and mortality. This article will firstly review the general causes of impaired bone health in muscular dystrophies and then focus on the evidence available for the diagnosis and treatment of osteoporosis in specific conditions. RECENT FINDINGS: With the exception of DMD, there is a paucity of data regarding bone health in muscular dystrophies. However, it appears that in common with all types of muscular dystrophies that cause a significant level of muscle weakness and disability there is an increased risk of falls, fractures and decreased vitamin D levels. A better understanding of the extent of the impaired bone health and underlying causes could help to identify potential new therapeutic agents and aid clinical care. SUMMARY: It would be prudent for clinicians to assess fracture risk in their muscular dystrophy patients and if appropriate, arrange surveillance and recommend vitamin D supplementation. Additionally, fracture should be considered in any patient presenting with new-onset bone pain.


Publication metadata

Author(s): Wood CL, Straub V

Publication type: Article

Publication status: Published

Journal: Current opinion in neurology

Year: 2018

Volume: 31

Issue: 5

Pages: 583-591

Print publication date: 01/10/2018

Online publication date: 01/10/2018

Acceptance date: 02/04/2016

ISSN (print): 1350-7540

ISSN (electronic): 1473-6551

Publisher: Lippincott Williams & Wilkins, Ltd.

URL: https://journals.lww.com/co-neurology/Fulltext/2018/10000/Bones_and_muscular_dystrophies___what_do_we_know_.12.aspx

DOI: 10.1097/WCO.0000000000000603

PubMed id: 30080716


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