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Activation induced changes in GABA: functional MRS at 7 T with MEGA-sLASER

Lookup NU author(s): Dr Hilmar Sigurdsson

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Abstract

Functional magnetic resonance spectroscopy (fMRS) has been used to assess the dynamic metabolic responses of the brain to a physiological stimulus non-invasively. However, only limited information on the dynamic functional response of γ-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the brain, is available. We aimed to measure the activation-induced changes in GABA unambiguously using a spectral editing method, instead of the conventional direct detection techniques used in previous fMRS studies. The Mescher-Garwood-semi-localised by adiabatic selective refocusing (MEGA-sLASER) sequence was developed at 7 T to obtain the time course of GABA concentration without macromolecular contamination. A significant decrease (−12±5%) in the GABA to total creatine ratio (GABA/tCr) was observed in the motor cortex during a period of 10 min of hand-clenching, compared to an initial baseline level (GABA/tCr =0.11±0.02) at rest. An increase in the Glx (glutamate and glutamine) to tCr ratio was also found, which is in agreement with previous findings. In contrast, no significant changes in NAA/tCr and tCr were detected. With consistent and highly efficient editing performance for GABA detection and the advantage of visually identifying GABA resonances in the spectra, MEGA-sLASER is demonstrated to be an effective method for studying of dynamic changes in GABA at 7 T.


Publication metadata

Author(s): Chen C, Sigurdsson HP, Pépés SE, Auer DP, Morris PG, Morgan PS, Gowland PA, Jackson SR

Publication type: Article

Publication status: Published

Journal: NeuroImage

Year: 2017

Volume: 156

Pages: 207-213

Print publication date: 01/08/2017

Online publication date: 19/05/2017

Acceptance date: 19/05/2017

ISSN (print): 1053-8119

ISSN (electronic): 1095-9572

Publisher: Elsevier

URL: https://doi.org/10.1016/j.neuroimage.2017.05.044

DOI: 10.1016/j.neuroimage.2017.05.044


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