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Lookup NU author(s): Dr Eleanor King, Dr Paul Donaghy, Dr Christopher Morris, Nicola Barnett, Kirsty OlsenORCiD, Dr Carmen Martin-RuizORCiD, Professor John-Paul TaylorORCiD, Professor Alan ThomasORCiD
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© International Psychogeriatric Association 2019. Objectives and design:To Investigate the peripheral inflammatory profile in patients with mild cognitive impairment (MCI) from three subgroups - probable Lewy body disease (probable MCI-LB), possible Lewy body disease, and probable Alzheimer's disease (probable MCI-AD) - as well as associations with clinical features.Setting:Memory clinics and dementia services.Participants:Patients were classified based on clinical symptoms as probable MCI-LB (n = 38), possible MCI-LB (n = 18), and probable MCI-AD (n = 21). Healthy comparison subjects were recruited (n = 20).Measurements:Ten cytokines were analyzed from plasma samples: interferon (IFN)-gamma, interleukin (IL)-1beta, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, and tumor necrosis factor (TNF)-alpha. C-reactive protein levels were investigated.Results:There was a higher level of IL-10, IL-1beta, IL-2, and IL-4 in MCI groups compared to the healthy comparison group (p < 0.0085). In exploratory analyses to understand these findings, the MC-AD group lower IL-1beta (p = 0.04), IL-2 (p = 0.009), and IL-4 (p = 0.012) were associated with increasing duration of memory symptoms, and in the probable MCI-LB group, lower levels of IL-1beta were associated with worsening motor severity (p = 0.002). In the possible MCI-LB, longer duration of memory symptoms was associated with lower levels of IL-1beta (p = 0.003) and IL-4 (p = 0.026).Conclusion:There is increased peripheral inflammation in patients with MCI compared to healthy comparison subjects regardless of the MCI subtype. These possible associations with clinical features are consistent with other work showing that inflammation is increased in early disease but require replication. Such findings have importance for timing of putative therapeutic strategies aimed at lowering inflammation.
Author(s): King E, O'Brien JT, Donaghy P, Morris C, Barnett N, Olsen K, Martin-Ruiz C, Taylor JP, Thomas AJ
Publication type: Article
Publication status: Published
Journal: International Psychogeriatrics
Year: 2019
Volume: 31
Issue: 4
Pages: 551-560
Print publication date: 01/04/2019
Online publication date: 11/03/2019
Acceptance date: 10/05/2018
ISSN (print): 1041-6102
ISSN (electronic): 1741-203X
Publisher: Cambridge University Press
URL: https://doi.org/10.1017/S1041610218001126
DOI: 10.1017/S1041610218001126
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