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Ways Forward for Tolerance-Inducing Cellular Therapies- an AFACTT Perspective

Lookup NU author(s): Professor Catharien Hilkens



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Clinical studies with cellular therapies using tolerance-inducing cells, such as tolerogenic antigen-presenting cells (tolAPC) and regulatory T cells (Treg) for the prevention of transplant rejection and the treatment of autoimmune diseases have been expanding the last decade. In this perspective, we will summarize the current perspectives of the clinical application of both tolAPC and Treg, and will address future directions and the importance of immunomonitoring in clinical studies that will result in progress in the field.

Publication metadata

Author(s): Ten Brinke A, Martinez-Llordella M, Cools N, Hilkens CMU, van Ham SM, Sawitzki B, Geissler EK, Lombardi G, Trzonkowski P, Martinez-Caceres E

Publication type: Review

Publication status: Published

Journal: Frontiers in immunology

Year: 2019

Volume: 10

Online publication date: 22/02/2019

Acceptance date: 21/01/2019

ISSN (electronic): 1664-3224

Publisher: NLM (Medline)


DOI: 10.3389/fimmu.2019.00181

PubMed id: 30853957