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© 2019 Elsevier Ltd Six novel fluorogenic enzyme substrates for detecting L-alanylaminopeptidase activity in microorganisms have been prepared and evaluated in Columbia agar media. The substrates are L-alanyl derivatives of 6-amino-2-hetarylquinolines and 7-amino-3-hetarylcoumarins. Both the quinoline and coumarin series of substrates produced fluorescence in the presence of Gram-negative microorganisms. In contrast, fluorescence generation in the presence of the Gram-positive microorganisms and yeasts was limited or absent.
Author(s): Cellier-Rastit M, James AL, Orenga S, Perry JD, Robinson SN, Turnbull G, Stanforth SP
Publication type: Article
Publication status: Published
Journal: Bioorganic and Medicinal Chemistry Letters
Pages: Epub ahead of print
Online publication date: 09/03/2019
Acceptance date: 09/03/2019
ISSN (print): 0960-894X
ISSN (electronic): 1464-3405
Publisher: Elsevier Ltd
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