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Lookup NU author(s): Martina Miotto
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A novel approach to produce artificial bone composites (microfibers)with distinctive features mimicking naturaltissue was investigated. Currently proposed inorganic materials (e.g. apatite matrixes) lack self-assembly andthereby limit interactions between cells and the material. The presentwork investigates the feasibility of creating“bio-inspired materials” specifically designed to overcome certain limitations inherent to current biomaterials.We examined the dimensions, morphology, and constitutive features of a composite hydrogel which combinedan alginate based microfiber with a gelatin solution or a particulate form of urinary bladder matrix (UBM). Theeffectiveness of the composite microfibers to induce and modulate osteoblastic differentiation in threedimensional(3D) scaffolds without altering the viability and morphological characteristics of the cells was investigated.The present study describes a novel alginate microfiber production methodwith the use of microfluidics.The microfluidic procedure allowed for precise tuning of microfibers which resulted in enhanced viability andfunction of embedded cells.
Author(s): Angelozzi M, Miotto M, Penolazzi L, Mazzitelli S, Keane T, Badylak SF, Piva R, Nastruzzi C
Publication type: Article
Publication status: Published
Journal: Materials Science and Engineering C
Year: 2015
Volume: 56
Pages: 141-153
Print publication date: 01/11/2015
Online publication date: 09/06/2015
Acceptance date: 06/06/2015
ISSN (print): 0928-4931
ISSN (electronic): 1873-0191
Publisher: Elsevier BV
URL: https://doi.org/10.1016/j.msec.2015.06.004
DOI: 10.1016/j.msec.2015.06.004
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