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Composite ECM–alginate microfibers produced by microfluidics as scaffolds with biomineralization potential

Lookup NU author(s): Martina Miotto


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A novel approach to produce artificial bone composites (microfibers)with distinctive features mimicking naturaltissue was investigated. Currently proposed inorganic materials (e.g. apatite matrixes) lack self-assembly andthereby limit interactions between cells and the material. The presentwork investigates the feasibility of creating“bio-inspired materials” specifically designed to overcome certain limitations inherent to current biomaterials.We examined the dimensions, morphology, and constitutive features of a composite hydrogel which combinedan alginate based microfiber with a gelatin solution or a particulate form of urinary bladder matrix (UBM). Theeffectiveness of the composite microfibers to induce and modulate osteoblastic differentiation in threedimensional(3D) scaffolds without altering the viability and morphological characteristics of the cells was investigated.The present study describes a novel alginate microfiber production methodwith the use of microfluidics.The microfluidic procedure allowed for precise tuning of microfibers which resulted in enhanced viability andfunction of embedded cells.

Publication metadata

Author(s): Angelozzi M, Miotto M, Penolazzi L, Mazzitelli S, Keane T, Badylak SF, Piva R, Nastruzzi C

Publication type: Article

Publication status: Published

Journal: Materials Science and Engineering C

Year: 2015

Volume: 56

Pages: 141-153

Print publication date: 01/11/2015

Online publication date: 09/06/2015

Acceptance date: 06/06/2015

ISSN (print): 0928-4931

ISSN (electronic): 1873-0191

Publisher: Elsevier BV


DOI: 10.1016/j.msec.2015.06.004


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