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Lookup NU author(s): Dr Emily ThompsonORCiD, Ellie Irwin, Dr Ibrahim Ibrahim, Dr Sam Tingle, Steven White, Professor Derek Manas, Professor Colin Wilson
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
© 2019 The Authors. Clinical Transplantation Published by John Wiley & Sons Ltd Substance abuse is unfortunately common in organ donors. Often, these organs are declined for transplant, not only because of concerns around blood-borne virus transmission but also because of perceived poor outcomes. In kidney transplantation, previous studies have demonstrated donor smoking status significantly impacts transplant outcome, but intravenous drug use or alcohol dependence does not. This study aims to clarify these issues in pancreas transplantation. Retrospective data on all UK solid organ pancreas transplants from 1994 to 2015 were obtained from the NHSBT UK Transplant Registry. The impact of illicit drug misuse, alcohol abuse, and smoking on graft and patient survival were analyzed using Kaplan-Meier plots and a Cox regression model. A total of 1175 of the 2317 (49.5%) donors were categorized as substance misusers. Univariate survival analysis revealed no significant impact of substance misuse on 10-year graft or patient survival. Multivariate analysis confirmed substance misuse was not associated with impaired graft or patient survival. A history of donor substance misuse does not negatively impact 10-year graft or patient survival following pancreas transplantation. This is a large national registry analysis with long-term follow-up data and should therefore provide clinicians with reassurance when considering pancreas grafts from substance misuse donors.
Author(s): Thompson ER, Irwin EA, Trotter P, Ibrahim IK, Tingle SJ, White SA, Manas DM, Wilson CH
Publication type: Article
Publication status: Published
Journal: Clinical Transplantation
Year: 2019
Volume: 33
Issue: 3
Print publication date: 01/03/2019
Online publication date: 19/01/2019
Acceptance date: 11/01/2019
Date deposited: 01/04/2019
ISSN (print): 0902-0063
ISSN (electronic): 1399-0012
Publisher: Blackwell Publishing Ltd
URL: https://doi.org/10.1111/ctr.13481
DOI: 10.1111/ctr.13481
PubMed id: 30659654
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