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Paediatric Focal Intracranial Suppurative Infection: a UK single-centre retrospective cohort study

Lookup NU author(s): Dr Stephen Ball, Professor Marieke Emonts-le ClercqORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


BackgroundPaediatric focal intracranial suppurative infections are uncommon but cause significant mortality and morbidity. There are no uniform guidelines regarding antibiotic treatment. This study reviewed management in a tertiary healthcare centre in the United Kingdom and considers suggestions for empirical treatment.MethodsA retrospective, single-centre cohort review of 95 children (<18 years of age) with focal intracranial suppurative infection admitted between January 2001 and June 2016 in Newcastle upon Tyne, United Kingdom. Microbiological profiles and empirical antibiotic regimens were analysed for coverage, administration and duration of use. Mortality and neurological morbidity were reviewed. Data was analysed using t-tests, Mann-Whitney U tests, independent-samples median tests, and

Publication metadata

Author(s): van der Velden FJS, Battersby A, Pareja-Cebrian L, Ross Nicholas, Ball SL, Emonts M

Publication type: Article

Publication status: Published

Journal: BMC Pediatrics

Year: 2019

Volume: 19

Online publication date: 25/04/2019

Acceptance date: 03/04/2019

Date deposited: 29/04/2019

ISSN (electronic): 1471-2431

Publisher: BioMed Central Ltd.


DOI: 10.1186/s12887-019-1486-7


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