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Lookup NU author(s): Professor Cathy Schevon,
Dr Edward Merricks,
Professor Andrew Trevelyan
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© 2019 Elsevier Inc. The cellular activity underlying human focal seizures, and its relationship to key signatures in the EEG recordings used for therapeutic purposes, has not been well characterized despite many years of investigation both in laboratory and clinical settings. The increasing use of microelectrodes in epilepsy surgery patients has made it possible to apply principles derived from laboratory research to the problem of mapping the spatiotemporal structure of human focal seizures, and characterizing the corresponding EEG signatures. In this review, we describe results from human microelectrode studies, discuss some data interpretation pitfalls, and explain the current understanding of the key mechanisms of ictogenesis and seizure spread.
Author(s): Schevon CA, Tobochnik S, Eissa T, Merricks E, Gill B, Parrish RR, Bateman LM, McKhann GM, Emerson RG, Trevelyan AJ
Publication type: Review
Publication status: Published
Journal: Neurobiology of Disease
Print publication date: 01/07/2019
Online publication date: 18/03/2019
Acceptance date: 15/03/2019
ISSN (print): 0969-9961
ISSN (electronic): 1095-953X
Publisher: Academic Press Inc.
PubMed id: 30898669