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Multiscale recordings reveal the dynamic spatial structure of human seizures

Lookup NU author(s): Professor Cathy Schevon, Dr Edward Merricks, Ryley Parrish, Professor Andrew Trevelyan


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© 2019 Elsevier Inc. The cellular activity underlying human focal seizures, and its relationship to key signatures in the EEG recordings used for therapeutic purposes, has not been well characterized despite many years of investigation both in laboratory and clinical settings. The increasing use of microelectrodes in epilepsy surgery patients has made it possible to apply principles derived from laboratory research to the problem of mapping the spatiotemporal structure of human focal seizures, and characterizing the corresponding EEG signatures. In this review, we describe results from human microelectrode studies, discuss some data interpretation pitfalls, and explain the current understanding of the key mechanisms of ictogenesis and seizure spread.

Publication metadata

Author(s): Schevon CA, Tobochnik S, Eissa T, Merricks E, Gill B, Parrish RR, Bateman LM, McKhann GM, Emerson RG, Trevelyan AJ

Publication type: Review

Publication status: Published

Journal: Neurobiology of Disease

Year: 2019

Volume: 127

Pages: 303-311

Print publication date: 01/07/2019

Online publication date: 18/03/2019

Acceptance date: 15/03/2019

ISSN (print): 0969-9961

ISSN (electronic): 1095-953X

Publisher: Academic Press Inc.


DOI: 10.1016/j.nbd.2019.03.015

PubMed id: 30898669