Molecularly Imprinted Polymers: Synthetic Receptors for Diagnostic Medical Devices. Synthetic Receptors for Diagnostic Medical Devices

Peeters, M; Eersels, K; Junkers, T; Wagner, P

doi:10.1016/B978-0-12-801301-4.00013-X

Molecularly Imprinted Polymers: Synthetic Receptors for Diagnostic Medical Devices. Synthetic Receptors for Diagnostic Medical Devices

Lookup NU author(s): Professor Marloes Peeters ORCiD

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

© 2016 Elsevier Inc. All rights reserved. In recent years, molecularly imprinted polymers (MIPs) have gained increasing interest in the bioanalytical field because they are extremely suitable for detecting chemical targets in complex matrices. Their incorporation into sensing devices remains challenging; however, we will present a straightforward sensor platform that is compatible with electrochemical impedance spectroscopy and a novel readout technique, the heat-transfer method. Impedimetric readout allows for specific detection of neurotransmitters in buffer solutions in the subnanomolar regime and was also evaluated for its use in biological samples such as blood plasma and bowel fluid. The heat-transfer method offers a more straightforward analysis compared with impedance spectroscopy, with similar detection limits in buffer solutions, although detection in biological samples still needs to be analyzed. We show a versatile MIP-based sensor platform that can detect small organic molecules in a fast and low-cost manner, opening the door to applications in biological samples.