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Molecularly Imprinted Polymers: Synthetic Receptors for Diagnostic Medical Devices. Synthetic Receptors for Diagnostic Medical Devices

Lookup NU author(s): Dr Marloes PeetersORCiD

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Abstract

© 2016 Elsevier Inc. All rights reserved. In recent years, molecularly imprinted polymers (MIPs) have gained increasing interest in the bioanalytical field because they are extremely suitable for detecting chemical targets in complex matrices. Their incorporation into sensing devices remains challenging; however, we will present a straightforward sensor platform that is compatible with electrochemical impedance spectroscopy and a novel readout technique, the heat-transfer method. Impedimetric readout allows for specific detection of neurotransmitters in buffer solutions in the subnanomolar regime and was also evaluated for its use in biological samples such as blood plasma and bowel fluid. The heat-transfer method offers a more straightforward analysis compared with impedance spectroscopy, with similar detection limits in buffer solutions, although detection in biological samples still needs to be analyzed. We show a versatile MIP-based sensor platform that can detect small organic molecules in a fast and low-cost manner, opening the door to applications in biological samples.


Publication metadata

Author(s): Peeters M, Eersels K, Junkers T, Wagner P

Publication type: Book Chapter

Publication status: Published

Book Title: Molecularly Imprinted Catalysts: Principles, Syntheses, and Applications

Year: 2015

Pages: 253-271

Online publication date: 05/02/2016

Acceptance date: 01/01/1900

Publisher: Elsevier Inc.

Place Published: Amsterdam

URL: https://doi.org/10.1016/B978-0-12-801301-4.00013-X

DOI: 10.1016/B978-0-12-801301-4.00013-X

Library holdings: Search Newcastle University Library for this item

ISBN: 9780128013014


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