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The heat-transfer method: A versatile low-cost, label-free, fast, and user-friendly readout platform for biosensor applications

Lookup NU author(s): Professor Marloes PeetersORCiD


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In recent years, biosensors have become increasingly important in various scientific domains including medicine, biology, and pharmacology, resulting in an increased demand for fast and effective readout techniques. In this Spotlight on Applications, we report on the recently developed heat-transfer method (HTM) and illustrate the use of the technique by zooming in on four established bio(mimetic) sensor applications: (i) mutation analysis in DNA sequences, (ii) cancer cell identification through surface-imprinted polymers, (III) detection of neurotransmitters with molecularly imprinted polymers, and (iv) phase-transition analysis in lipid vesicle layers. The methodology is based on changes in heat-transfer resistance at a functionalized solid-liquid interface. To this extent, the device applies a temperature gradient over this interface and monitors the temperature underneath and above the functionalized chip in time. The heat-transfer resistance can be obtained by dividing this temperature gradient by the power needed to achieve a programmed temperature. The low-cost, fast, label-free and user-friendly nature of the technology in combination with a high degree of specificity, selectivity, and sensitivity makes HTM a promising sensor technology. © 2014 American Chemical Society.

Publication metadata

Author(s): Van Grinsven B, Eersels K, Peeters M, Losada-Perez P, Vandenryt T, Cleij TJ, Wagner P

Publication type: Article

Publication status: Published

Journal: ACS Applied Materials and Interfaces

Year: 2014

Volume: 6

Issue: 16

Pages: 13309-13318

Print publication date: 27/08/2014

Online publication date: 08/08/2014

Acceptance date: 08/08/2014

ISSN (print): 1944-8244

ISSN (electronic): 1944-8252

Publisher: American Chemical Society


DOI: 10.1021/am503667s

PubMed id: 25105260


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