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Lookup NU author(s): Dr Zheyu Xu,
Dr Kirstie Anderson
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© 2019 Elsevier B.V. Background: It is now recognized that the vast majority of individuals with typical RBD will develop a synucleinopathy; usually 11–16 years after symptom onset. Parasomnia Overlap Disorder (POD) with adolescent-onset dream enactment behavior with phenoconversion to neurodegenerative disease after a long latency has not been previously described. Patient: We present a case of a 65-year-old man with presumptive POD who had co-morbid childhood onset sleep walking and adolescent-onset dream enactment behavior beginning at age 17, with subsequent evolution to an increasingly troublesome REM sleep behavior disorder (RBD) at age 64 with Parkinson's Disease (PD) developing a year later. Results: Polysomnography performed at age 64 was consistent with a diagnosis of RBD. Dream enactment behavior preceded PD diagnosis by at least 48 years. Our case represents the youngest reported RBD case who developed PD. Conclusions: We report the first case of adolescent onset, presumed RBD in the context of presumptive POD developing neurodegenerative disease. Adolescent-onset RBD may have similar prognostic implications as typical RBD, where future phenoconversion to a synucleinopathy is expected.
Author(s): Xu Z, Oliver JR, Anderson KN
Publication type: Article
Publication status: Published
Journal: Sleep Medicine
Print publication date: 01/05/2019
Online publication date: 12/02/2019
Acceptance date: 31/01/2019
ISSN (print): 1389-9457
ISSN (electronic): 1878-5506
Publisher: Elsevier BV
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