Toggle Main Menu Toggle Search

Open Access padlockePrints

The adjunctive application of transcranial direct current stimulation in the management of de novo refractory epilepsia partialis continua in adolescent-onset POLG-related mitochondrial disease

Lookup NU author(s): Dr Yi Ng, Dr Henriette van Ruiten, Dr Vankateswara Ramesh, Professor Robert Taylor, Professor Doug Turnbull, Dr Grainne Gorman, Professor Bobby McFarland, Dr Mark Baker

Downloads


Licence

This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© 2017 The Authors. Epilepsia Open published by Wiley Periodicals Inc. on behalf of International League Against Epilepsy. Focal status epilepticus in POLG-related mitochondrial disease is highly refractory to pharmacological agents, including general anesthesia. We report the challenges in managing a previously healthy teenager who presented with de novo epilepsia partialis continua and metabolic stroke resulting from the homozygous p.Ala467Thr POLG mutation, the most common pathogenic variant identified in the Caucasian population. We applied transcranial direct current stimulation (tDCS; 2 mA; 20 min) daily as an adjunctive therapy because her focal seizures failed to respond to five antiepileptic drugs at maximal doses. The electrical and clinical seizures stopped after 3 days of tDCS. The second course of tDCS was administered for 14 days when the focal seizures re-emerged a month later. The patient tolerated the procedure well. Following 4 months of hospitalization and prolonged community rehabilitation, our patient has now returned to full-time education with support, and there is no report of cognitive deficit. We have demonstrated the safety and efficacy of tDCS in treating refractory focal motor seizures caused by mitochondrial disease.


Publication metadata

Author(s): Ng YS, van Ruiten H, Lai HM, Scott R, Ramesh V, Horridge K, Taylor RW, Turnbull DM, Gorman GS, McFarland R, Baker MR

Publication type: Article

Publication status: Published

Journal: Epilepsia Open

Year: 2018

Volume: 3

Issue: 1

Pages: 103-108

Print publication date: 01/03/2018

Online publication date: 06/12/2017

Acceptance date: 20/11/2017

Date deposited: 23/04/2019

ISSN (electronic): 2470-9239

Publisher: Wiley-Blackwell Publishing Ltd

URL: https://doi.org/10.1002/epi4.12094

DOI: 10.1002/epi4.12094


Altmetrics

Altmetrics provided by Altmetric


Actions

Find at Newcastle University icon    Link to this publication


Share