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New evidence on the management of Lewy body dementia

Lookup NU author(s): Professor John-Paul TaylorORCiD, Professor Ian McKeith, Professor David Burn, Claire BamfordORCiD, Professor Alan ThomasORCiD, Professor John O'Brien



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Dementia with Lewy bodies and Parkinson’s disease dementia, jointly known as Lewy body dementia (LBD), are common neurodegenerative conditions. Patients with LBD present with a wide range of cognitive, neuropsychiatric, sleep, motor, and autonomic symptoms. The expression of these varies between individual patients, and over time. Treatments may benefit one symptom, but at the expense of worsening another, making management difficult. Often symptoms are managed in isolation and by different specialists, which undermines high quality care. Clinical trials and meta-analyses now provide an improved evidence base for the treatment of cognitive, neuropsychiatric and motor symptoms in LBD, in addition to which expert consensus opinion supports the application of treatments from related conditions such as Parkinson’s disease (PD) for the management of, for example, autonomic symptoms. There remain however clear evidence gaps and there is a high need for future clinical trials focused on specific symptoms in LBD.

Publication metadata

Author(s): Taylor J-P, McKeith IG, Burn D, Boeve B, Weintraub D, Bamford C, Allan L, Thomas AJ, O'Brien JT

Publication type: Review

Publication status: Published

Journal: The Lancet Neurology

Year: 2020

Volume: 19

Issue: 2

Pages: 157-169

Print publication date: 01/02/2020

Online publication date: 10/09/2019

Acceptance date: 29/03/2019

ISSN (print): 1474-4422

ISSN (electronic): 1474-4465


DOI: 10.1016/S1474-4422(19)30153-X