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Lookup NU author(s): Professor John-Paul TaylorORCiD, Professor Ian McKeith, Professor David BurnORCiD, Claire BamfordORCiD, Professor Alan ThomasORCiD, Professor John O'Brien
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
Dementia with Lewy bodies and Parkinson’s disease dementia, jointly known as Lewy body dementia (LBD), are common neurodegenerative conditions. Patients with LBD present with a wide range of cognitive, neuropsychiatric, sleep, motor, and autonomic symptoms. The expression of these varies between individual patients, and over time. Treatments may benefit one symptom, but at the expense of worsening another, making management difficult. Often symptoms are managed in isolation and by different specialists, which undermines high quality care. Clinical trials and meta-analyses now provide an improved evidence base for the treatment of cognitive, neuropsychiatric and motor symptoms in LBD, in addition to which expert consensus opinion supports the application of treatments from related conditions such as Parkinson’s disease (PD) for the management of, for example, autonomic symptoms. There remain however clear evidence gaps and there is a high need for future clinical trials focused on specific symptoms in LBD.
Author(s): Taylor J-P, McKeith IG, Burn D, Boeve B, Weintraub D, Bamford C, Allan L, Thomas AJ, O'Brien JT
Publication type: Review
Publication status: Published
Journal: The Lancet Neurology
Year: 2020
Volume: 19
Issue: 2
Pages: 157-169
Print publication date: 01/02/2020
Online publication date: 10/09/2019
Acceptance date: 29/03/2019
ISSN (print): 1474-4422
ISSN (electronic): 1474-4465
URL: https://doi.org/10.1016/S1474-4422(19)30153-X
DOI: 10.1016/S1474-4422(19)30153-X
