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CAR T-cell bioengineering: Single variable domain of heavy chain antibody targeted CARs

Lookup NU author(s): Professor Moein MoghimiORCiD

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Abstract

© 2019 Elsevier B.V. Redirecting the recognition specificity of T lymphocytes to designated tumour cell surface antigens by transferring chimeric antigen receptor (CAR) genes is becoming an effective strategy to combat cancer. Today, CAR T-cell therapy has proven successful in the treatment of haematological malignancies and the first CD19 CAR T-cell products has already entered the market. This success is expanding CAR design for broader malignancies including solid tumours. Nevertheless, CARs such as those built on antigen-specific single chain antibody variable fragment (scFv) may induce some adverse effects. Here, we briefly review CAR T-cell bioengineering and discuss selected important initiatives for improved T-cell reprogramming, function and safety. In this respect, we further elaborate on unconventional CARs structured on single variable domain of heavy chain (VHH) antibodies (single-domain antibodies) as an alternative to scFv, because of their interesting immunological and physicochemical characteristics and unique structure, which shows a high degree of homology with human VH3 gene family.

Publication metadata

Author(s): Rahbarizadeh F, Ahmadvand D, Moghimi SM

Publication type: Article

Publication status: Published

Journal: Advanced Drug Delivery Reviews

Year: 2019

Volume: 141

Pages: 41-46

Print publication date: 15/02/2019

Online publication date: 17/04/2019

Acceptance date: 15/04/2019

ISSN (print): 0169-409X

ISSN (electronic): 1872-8294

Publisher: Elsevier BV

URL: https://doi.org/10.1016/j.addr.2019.04.006

DOI: 10.1016/j.addr.2019.04.006

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