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Bioinspired Antimicrobial Nanodots with Amphiphilic and Zwitterionic-like Characteristics for Combating Multidrug-Resistant Bacteria and Biofilm Removal

Lookup NU author(s): Professor Yen Nee Tan

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Abstract

Inspired by the natural antimicrobial peptides, we have developed a benign antimicrobial nanodot (BAM dot) via a simple one-step hydrothermal synthesis. The BAM dot possesses the unique properties of both nanoparticles and biomaterials, leading to excellent antibacterial properties with a high therapeutic index. Specifically, this BAM dot has ultrasmall size (3.83 ± 0.73 nm) with a charged neutral surface. They also exhibited amphiphilic and zwitterionic-like properties, which enabled effective bacteria membrane permeabilization, leading to a rapid bactericidal effect and significant biofilm removal. This study opens up new opportunities to design effective bioinspired nanomaterials for combating superbugs against drug resistance and their related applications.

Publication metadata

Author(s): Xu HV, Zheng XT, Wang C, Zhao Y, Tan YN

Publication type: Article

Publication status: Published

Journal: ACS Applied Nano Materials

Year: 2018

Volume: 1

Issue: 5

Pages: 2062-2068

Print publication date: 25/05/2018

Online publication date: 17/05/2018

Acceptance date: 08/05/2018

ISSN (electronic): 2574-0970

Publisher: American Chemical Society

URL: https://doi.org/10.1021/acsanm.8b00465

DOI: 10.1021/acsanm.8b00465

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