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Differential immune response to Eimeria maxima infection in fast and slow growing broiler genotypes

Lookup NU author(s): Dr Panagiotis Sakkas, Professor Ilias Kyriazakis



This is the authors' accepted manuscript of an article that has been published in its final definitive form by Wiley-Blackwell Publishing Ltd., 2019.

For re-use rights please refer to the publisher's terms and conditions.


Very little has been reported comparing resistance to coccidiosis in fast or slow growing broilers, the latter of which are becoming more prevalent in the broiler industry. We examined mRNA expression in the intestines of fast and slow growing broilers following Eimeria infection. We show that by day 13 post infection (d pi) with 2500 or 7000 oocysts of E. maxima, slower growing (Ranger Classic) broilers significantly (P <0.01) up-regulated expression of proinflammatory cyclooxygenase genes (LTB4DH, PTSG1 and PTSG2) above that detected in fast growing (Ross 308) broilers. Expression of CD8α mRNA was down-regulated in Ross 308 at day 6d pi with either 2500 or 7000 oocysts of E. maxima (P <0.05), compared to uninfected controls, but was not differentially expressed in Ranger Classic. CD4 genes were not differentially expressed in either chicken line infected with either infectious oocyst dose at d6 pi, compared to uninfected controls. However, at d13 pi, CD4 expression was significantly up-regulated in both chicken lines infected with either infectious oocyst, compared to uninfected controls (P< 0.05) but this was significantly greater in Ranger Classic broilers compared to Ross 308 (P <0.05). At d13 pi, expression of CD3 chains (required for T lymphocyte activation) were significantly increased in Ranger Classic compared to Ross 308 infected with either oocyst dose (P <0.05-0.01). Expression of IL-2 and IL-15 mRNA, required for T lymphocyte proliferation, was also significantly up-regulated, or maintained longer, in Ranger Classic broilers compared to Ross 308. These differences in immune response to E. maxima corresponded with a reduction in E. maxima genome detected in the intestines of Ranger Classic compared to Ross 308.

Publication metadata

Author(s): Giles T, Sakkas P, Belkiri A, Barrow P, Kyriazakis I, Foster N

Publication type: Article

Publication status: Published

Journal: Parasite Immunology

Year: 2019

Volume: 41

Issue: 9

Print publication date: 01/09/2019

Online publication date: 23/06/2019

Acceptance date: 14/06/2019

Date deposited: 14/06/2019

ISSN (print): 0141-9838

ISSN (electronic): 1365-3024

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1111/pim.12660


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Funder referenceFunder name
613574European Commission