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A new in vivo and in vitro B cell lymphoma model, pi-BCL1

Lookup NU author(s): Dr Bridget Wilkins


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We report a new variant of the BCL1 syngeneic mouse B-cell lymphoma model, which we have called pi-BCL1. pi-BCL1 can be established as a syngeneic tumor in BALB/c mice. Tumors can be removed, prepared and easily grown in liquid culture and subsequently transferred back successfully as syngeneic tumors. As a syngeneic tumor pi-BCL1 behave more like a lymphoma with solid tumor masses, than a chronic lymphocytic leukaemia of the original BCL1 model. The immunophenotype and the growth characteristics of the pi-BCL1 and BCL1 tumors appear very similar. Cytologically, pi-BCL1 appears to be a transformation from a small lymphocytic lymphoma to a more diffuse large cell centroblast-like higher-grade lymphoma. We are not aware of any previous reports of such transformation events in a syngeneic animal model of B cell lymphoma. We believe pi-BCL1 provides a useful new tool for the study of B cell lymphoma in vitro and in vivo and enables reduced numbers of tumor passage in mice.

Publication metadata

Author(s): Illidge T, Honeychurch J, Howatt W, Ross F, Wilkins BS, Cragg M

Publication type: Article

Publication status: Published

Journal: Cancer Biotherapy & Radiopharmaceuticals

Year: 2000

Volume: 15

Issue: 6

Pages: 571-580

ISSN (print): 1084-9785

ISSN (electronic): 1557-8852

Publisher: Mary Ann Liebert, Inc. Publishers


DOI: 10.1089/cbr.2000.15.571


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