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BRAF Wild-type, PTEN Mutant Malignant Uveal Melanoma Arising Within a Mature Ovarian Teratoma: A Case Report and Review of the Literature

Lookup NU author(s): Ali Kucukmetin, Dr Nicola Cresti, Dr Rachel O'DonnellORCiD



This is the authors' accepted manuscript of an article that has been published in its final definitive form by Lippincott Williams and Wilkins, 2020.

For re-use rights please refer to the publisher's terms and conditions.


Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved. Mature cystic teratomas are common in women of all ages; however, malignant transformation within them is rare and difficult to diagnosis preoperatively. Primary melanoma of the ovary is exceptionally rare and only occurs in relation to a teratoma where it can originate from sporadic somatic mutagenesis within epidermal junctional melanocytes, through malignant transformation of a benign nevus formed within the mature cystic teratoma or from other well differentiated pigment-containing structures such as the uvea. We present a case of primary malignant melanoma arising within a mature cystic teratoma in a young patient, who ultimately developed widespread metastasis necessitating systemic therapy. Our case highlights the role of molecular medicine not only in forming an understanding the origin of the melanoma, but also guiding targeted systemic therapies. Alongside the case we present a review of the literature describing the incidence of molecular aberrations within melanoma as well as the established and emerging techniques and cytotoxic agents for malignant melanoma.

Publication metadata

Author(s): Lengyel K, Young F, Kucukmetin A, Cresti N, Plummer R, Ralte A, O'Donnell RL

Publication type: Article

Publication status: Published

Journal: International Journal of Gynecological Pathology

Year: 2020

Volume: 39

Issue: 4

Pages: 321-326

Print publication date: 01/07/2020

Online publication date: 31/05/2019

Acceptance date: 02/04/2018

Date deposited: 17/10/2019

ISSN (print): 0277-1691

ISSN (electronic): 1538-7151

Publisher: Lippincott Williams and Wilkins


DOI: 10.1097/PGP.0000000000000614


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