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Fatigue and cognitive impairment in immune thrombocytopenic purpura remain stable over time: short report from a longitudinal study

Lookup NU author(s): Eleanor MitchellORCiD, Dr James FrithORCiD, Emerita Professor Julia Newton


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© 2019 British Society for Haematology and John Wiley & Sons Ltd. Immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterised by low platelet counts and increased bleeding risk. In 2009, two cross-sectional studies determined that fatigue and cognitive impairment (CI) were common in ITP. Here, we report the results from a longitudinal study of 34 people with ITP. Fatigue severity remained unchanged over 7 years, and CI significantly improved. Future fatigue and CI severity could be predicted using baseline severity scores. These findings may be reassuring for ITP patients, as symptoms remain stable over time. Furthermore, using baseline scores to predict future severity could aid the clinical management of ITP.

Publication metadata

Author(s): Mitchell E, Frith J, Newton J

Publication type: Article

Publication status: Published

Journal: British Journal of Haematology

Year: 2019

Volume: 186

Issue: 5

Pages: 777-781

Print publication date: 01/09/2019

Online publication date: 23/05/2019

Acceptance date: 11/04/2019

ISSN (print): 0007-1048

ISSN (electronic): 1365-2141

Publisher: Wiley-Blackwell


DOI: 10.1111/bjh.15993

PubMed id: 31119732


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