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An intracellular pathogen response pathway promotes proteostasis in C. elegans

Lookup NU author(s): Dr Johan PanekORCiD

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Abstract

Maintenance of protein homeostasis, or proteostasis, is crucial for organismal health. Disruption of proteostasis can lead to the accumulation of protein aggregates, which are associated with aging and many human diseases such as Alzheimer’s disease [1, 2, 3]. Through analysis of the C. elegans host response to intracellular infection, we describe here a novel response pathway that enhances proteostasis capacity and appears to act in parallel to well-studied proteostasis pathways. These findings are based on analysis of the transcriptional response to infection by the intracellular pathogen Nematocida parisii[4]. The response to N. parisii is strikingly similar to the response to infection by the Orsay virus, another natural intracellular pathogen of C. elegans, and is distinct from responses to extracellular pathogen infection [4, 5, 6]. We have therefore named this common transcriptional response the intracellular …

Publication metadata

Author(s): Reddy C, Dror T, Sowa JN, Panek J, Chen K, Lim ES, Wang D, Troemel ER

Publication type: Article

Publication status: Published

Journal: Current Biology

Year: 2017

Volume: 17

Issue: 22

Pages: 3544-3553.e5

Print publication date: 20/11/2017

Online publication date: 02/11/2017

Acceptance date: 03/10/2017

ISSN (print): 0960-9822

ISSN (electronic): 1879-0445

Publisher: Cell Press

URL: https://doi.org/10.1016/j.cub.2017.10.009

DOI: 10.1016/j.cub.2017.10.009

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