Lookup NU author(s): Professor Nicholas Embleton
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© 2019 Elsevier Inc. Proteins are key structural components of all human cells and are also involved in key physiologic processes through their roles as enzymes, hormones and transport proteins. Protein requirements are substantially higher in preterm infants than those born at term, yet inadequate protein intakes are a common problem on many neonatal units. Very preterm infants (VPT, <32 weeks) commonly receive parenteral amino acid solutions which are typically commenced on admission, and increased over the next few days. Several recent studies have explored differing parenteral amino acid intakes in the first few days, and recommendations have recently been updated. Parenteral nutrition intakes are decreased as enteral feeds are tolerated, but human milk alone will not meet protein needs in most VPT and supplementation or fortification will be required. This review paper considers basic protein and amino acid physiology in the newborn period, and the evidence base for current recommendations.
Author(s): Embleton ND, van den Akker CHP
Publication type: Review
Publication status: Published
Journal: Seminars in Perinatology
Pages: Epub ahead of print
Online publication date: 22/06/2019
Acceptance date: 02/04/2018
ISSN (print): 0146-0005
ISSN (electronic): 1558-075X
Publisher: W.B. Saunders