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Mesenchymal stromal cells for ocular surface repair

Lookup NU author(s): Olla Al-Jaibaji, Dr Steve Swioklo, Professor Che Connon

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Abstract

© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.Introduction: Cornea is a transparent, robust tissue that comprises highly organized cells. Disruption of this specialized tissue can lead to scarring and subsequent blindness, making corneal damage a considerable challenge worldwide. At present, the available medical treatments are unable to address the wide range of corneal diseases. Mesenchymal stem cells (MSCs) have increasingly been investigated for their regenerative effect on ocular surface injury due to their unique ability for growth factor production, anti-inflammatory activity, immunomodulatory capacity and differentiation into multiple cell lineages. Areas covered: Within this review, we explore the pathogenesis of corneal disorders in response to injury and disease, and the potential for MSCs to modulate this process as a treatment. Through the review of over 25 animal studies, we investigate the common mechanisms of action by which MSCs have their effect and discuss their potential for treating and/or preventing corneal deterioration. Expert opinion: Depending on the environmental cues, MSCs can exert a potent effect on corneal wound healing through reducing opacity and vascularization, whilst promoting re-epithelialization. Whilst their mechanism is multifactorial, it seems clear that the anti-inflammatory/immunomodulatory factors they produce in response to damage are key to their control of cellular milieu and improving healing outcomes.


Publication metadata

Author(s): Al-Jaibaji O, Swioklo S, Connon CJ

Publication type: Review

Publication status: Published

Journal: Expert Opinion on Biological Therapy

Year: 2019

Volume: 19

Issue: 7

Pages: 643-653

Online publication date: 12/04/2019

Acceptance date: 10/04/2019

ISSN (print): 1471-2598

ISSN (electronic): 1744-7682

Publisher: Taylor and Francis Ltd

URL: https://doi.org/10.1080/14712598.2019.1607836

DOI: 10.1080/14712598.2019.1607836

PubMed id: 30979344


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