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Type 2 diabetes remission: economic evaluation of the DiRECT/Counterweight-Plus weight management programme within a primary care randomized controlled trial

Lookup NU author(s): Professor Roy Taylor



This is the authors' accepted manuscript of an article that has been published in its final definitive form by Wiley-Blackwell, 2019.

For re-use rights please refer to the publisher's terms and conditions.


© 2019 Diabetes UK. Aim: The Counterweight-Plus weight management programme achieved 46% remission of Type 2 diabetes at 1 year in the DiRECT trial. We estimated the implementation costs of the Counterweight-Plus programme and its 1-year cost-effectiveness in terms of diabetes remission, compared with usual care, from the UK National Health Service (NHS) perspective. Methods: Within-trial total costs included programme set-up and running costs (practitioner appointment visits, low-energy formula diet sachets and training), oral anti-diabetes and anti-hypertensive medications, and healthcare contacts. Total costs were calculated for aggregated resource use for each participant and 95% confidence intervals (CI) were based on 1000 non-parametric bootstrap iterations. Results: One-year programme costs under trial conditions were estimated at £1137 per participant (95% CI £1071, £1205). The intervention led to a significant cost-saving of £120 (95% CI £78, £163) for the oral anti-diabetes drugs and £14 (95% CI £7.9, £22) for anti-hypertensive medications compared with the control. Deducting the cost-savings of all healthcare contacts from the intervention cost resulted an incremental cost of £982 (95% CI £732, £1258). Cost per 1 year of diabetes remission was £2359 (95% CI £1668, £3250). Conclusions: Remission of Type 2 diabetes within 1-year can be achieved at a cost below the annual cost of diabetes (including complications). Providing a reasonable proportion of remissions can be maintained over time, with multiple medical gains expected, as well as immediate social benefits, there is a case for shifting resources within diabetes care budgets to offer support for people with Type 2 diabetes to attempt remission. (Clinical Trial Registry No.: ISRCTN03267836).

Publication metadata

Author(s): Xin Y, Davies A, McCombie L, Briggs A, Messow C-M, Grieve E, Leslie WS, Taylor R, Lean MEJ

Publication type: Article

Publication status: Published

Journal: Diabetic Medicine

Year: 2019

Volume: 36

Issue: 8

Pages: 1003-1012

Print publication date: 01/08/2019

Online publication date: 26/04/2019

Acceptance date: 24/04/2019

Date deposited: 14/02/2020

ISSN (print): 0742-3071

ISSN (electronic): 1464-5491

Publisher: Wiley-Blackwell


DOI: 10.1111/dme.13981

PubMed id: 31026353


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Funder referenceFunder name
13/0004691Diabetes UK