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Mechanisms of antibiotics inhibiting bacterial RNA polymerase

Lookup NU author(s): Dr Hamed Mosaei Sejzi, John Harbottle

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Abstract

© 2019 The Author(s). Transcription, the first phase of gene expression, is performed by the multi-subunit RNA polymerase (RNAP). Bacterial RNAP is a validated target for clinical antibiotics. Many natural and synthetic compounds are now known to target RNAP, inhibiting various stages of the transcription cycle. However, very few RNAP inhibitors are used clinically. A detailed knowledge of inhibitors and their mechanisms of action (MOA) is vital for the future development of efficacious antibiotics. Moreover, inhibitors of RNAP are often useful tools with which to dissect RNAP function. Here, we review the MOA of antimicrobial transcription inhibitors.

Publication metadata

Author(s): Mosaei H, Harbottle J

Publication type: Review

Publication status: Published

Journal: Biochemical Society Transactions

Year: 2019

Volume: 47

Issue: 1

Pages: 339-350

Print publication date: 01/02/2019

Online publication date: 15/01/2019

Acceptance date: 15/01/2019

ISSN (print): 0300-5127

ISSN (electronic): 1470-8752

Publisher: Portland Press Ltd

URL: https://doi.org/10.1042/BST20180499

DOI: 10.1042/BST20180499

PubMed id: 30647141

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