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Lookup NU author(s): Emma Scott,
Professor Quentin AnsteeORCiD
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© Royal College of Physicians 2018. All rights reserved. Alcohol-related liver disease (ARLD) and non-alcoholic fatty liver disease (NAFLD) are leading causes of chronic liver disease globally. Both ARLD and NAFLD are multifactorial and refer to a spectrum of disease severity, ranging from steatosis through steatohepatitis to fibrosis and cirrhosis. Both diseases exhibit substantial inter-patient variation in long-term outcomes and are best considered complex disease traits where genetic and environmental factors interact to mediate disease severity and progression. Here, we briefly review the current literature describing the best validated genetic modifiers that influence severity of these liver conditions, including variants of the genes PNPLA3, TM6SF2 and MBOAT7, which have also been implicated in lipid dysregulation.
Author(s): Scott E, Anstee QM
Publication type: Review
Publication status: Published
Journal: Clinical Medicine
Online publication date: 26/04/2018
Acceptance date: 02/04/2016
ISSN (print): 1470-2118
ISSN (electronic): 1473-4893
Publisher: Royal College of Physicians
PubMed id: 29700094