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Genetics of alcoholic liver disease and non-alcoholic steatohepatitis

Lookup NU author(s): Emma Scott, Professor Quentin AnsteeORCiD


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© Royal College of Physicians 2018. All rights reserved. Alcohol-related liver disease (ARLD) and non-alcoholic fatty liver disease (NAFLD) are leading causes of chronic liver disease globally. Both ARLD and NAFLD are multifactorial and refer to a spectrum of disease severity, ranging from steatosis through steatohepatitis to fibrosis and cirrhosis. Both diseases exhibit substantial inter-patient variation in long-term outcomes and are best considered complex disease traits where genetic and environmental factors interact to mediate disease severity and progression. Here, we briefly review the current literature describing the best validated genetic modifiers that influence severity of these liver conditions, including variants of the genes PNPLA3, TM6SF2 and MBOAT7, which have also been implicated in lipid dysregulation.

Publication metadata

Author(s): Scott E, Anstee QM

Publication type: Review

Publication status: Published

Journal: Clinical Medicine

Year: 2018

Volume: 18

Pages: s54-s59

Online publication date: 26/04/2018

Acceptance date: 02/04/2016

ISSN (print): 1470-2118

ISSN (electronic): 1473-4893

Publisher: Royal College of Physicians


DOI: 10.7861/clinmedicine.18-2-s54

PubMed id: 29700094