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Lookup NU author(s): Emily Glover,
Professor Neil SheerinORCiD
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© 2019Urinary tract infection is one of the most common infections to affect humans. Uncomplicated infections most commonly occur in otherwise healthy women when uropathogenic bacteria, usually Escherichia coli, enter the bladder and overcome host innate immunity. Complicated infections occur in patients with an anatomical or functional abnormality of the urinary tract. Diagnosis is made on the basis of symptoms, and diagnostic precision is improved by urinalysis. Urine culture is important in patients with severe, recurrent or complicated infection and when diagnosis is uncertain, for example in children and elderly people. Most women with symptoms that resolve quickly do not require further investigation, but imaging of the renal tract, functional testing and cystoscopy should be considered in children, men and patients with recurrent or severe infection. Empirical antibiotic treatment started on the basis of symptoms and directed by urinalysis is suitable for uncomplicated cystitis but should be altered based on culture results for more severe infections. Three days of antibiotic treatment is usually sufficient for uncomplicated cystitis in women. Long-term or post-coital antibiotics are effective for patients with recurrent infection.
Author(s): Glover EK, Sheerin NS
Publication type: Review
Publication status: Published
Print publication date: 01/09/2019
Online publication date: 29/07/2019
Acceptance date: 02/04/2016
ISSN (print): 1357-3039
ISSN (electronic): 1365-4357
Publisher: Elsevier Ltd