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Lookup NU author(s): Dr Aimen Amer,
Professor Colin Wilson,
Professor Derek Manas
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© 2019 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical OncologyIndications for liver transplantation have expanded over the past few decades owing to improved outcomes and better understanding of underlying pathologies. In particular, there has been a growing interest in the field of transplant oncology in recent years that has led to considerable developments which have pushed the boundaries of malignant indications for liver transplantation beyond hepatocellular carcinoma (HCC). In this article, we review and summarise the published evidence for liver transplantation in non-HCC primary and metastatic liver malignancies and highlight ongoing clinical trials that address unresolved questions therein. We also examine the current technical, immunological and oncological challenges that face liver transplantation in this growing field and explore potential approaches to overcome these barriers.
Author(s): Amer A, Wilson CH, Manas DM
Publication type: Review
Publication status: Published
Journal: European Journal of Surgical Oncology
Print publication date: 01/12/2019
Online publication date: 24/07/2019
Acceptance date: 18/07/2019
ISSN (print): 0748-7983
ISSN (electronic): 1532-2157
Publisher: W.B. Saunders Ltd