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Liver transplantation for unresectable malignancies: Beyond hepatocellular carcinoma

Lookup NU author(s): Dr Aimen Amer, Professor Colin Wilson, Professor Derek Manas


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© 2019 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical OncologyIndications for liver transplantation have expanded over the past few decades owing to improved outcomes and better understanding of underlying pathologies. In particular, there has been a growing interest in the field of transplant oncology in recent years that has led to considerable developments which have pushed the boundaries of malignant indications for liver transplantation beyond hepatocellular carcinoma (HCC). In this article, we review and summarise the published evidence for liver transplantation in non-HCC primary and metastatic liver malignancies and highlight ongoing clinical trials that address unresolved questions therein. We also examine the current technical, immunological and oncological challenges that face liver transplantation in this growing field and explore potential approaches to overcome these barriers.

Publication metadata

Author(s): Amer A, Wilson CH, Manas DM

Publication type: Review

Publication status: Published

Journal: European Journal of Surgical Oncology

Year: 2019

Volume: 45

Issue: 12

Pages: 2268-2278

Print publication date: 01/12/2019

Online publication date: 24/07/2019

Acceptance date: 18/07/2019

ISSN (print): 0748-7983

ISSN (electronic): 1532-2157

Publisher: W.B. Saunders Ltd


DOI: 10.1016/j.ejso.2019.07.024