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Re-assessing the total burden of norovirus circulating in the United Kingdom population

Lookup NU author(s): Professor Sarah O'Brien



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


The second Infectious Intestinal Diseases study (IID2) estimated the incidence of norovirus in the UK at 47/1000 population (three million cases annually). Clinically significant norovirus was defined using a cycle threshold (ct) value of <30; a more stringent cut-off than used in diagnostic laboratories. The low infectious dose of norovirus means asymptomatic individuals potentially contribute to ongoing transmission. Using a less stringent but diagnostically relevant threshold increases the estimation of the population burden of norovirus infection by around 26% to 59/1000 person years (95% CI 52.32–64.98), equating to 3.7 million norovirus infections annually (3.3–4.1 million). With possible vaccines on the horizon for norovirus, having a good estimate of the total burden of norovirus infection, as well as symptomatic disease will be useful in helping to guide vaccination policy when candidate vaccines become available.

Publication metadata

Author(s): Harris JP, Iturriza-Gomara M, O'Brien SJ

Publication type: Article

Publication status: Published

Journal: Vaccine

Year: 2017

Volume: 35

Issue: 6

Pages: 853-855

Print publication date: 07/02/2017

Online publication date: 13/01/2017

Acceptance date: 06/01/2017

Date deposited: 13/08/2019

ISSN (print): 0264-410X

ISSN (electronic): 1873-2518

Publisher: Elsevier


DOI: 10.1016/j.vaccine.2017.01.009

PubMed id: 28094075


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