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Community-based surveillance of norovirus disease: A systematic review

Lookup NU author(s): Professor Sarah O'Brien



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2017 The Author(s). Background: Norovirus is a common cause of infectious gastrointestinal disease. Despite the increased ability to detect norovirus in affected people, the number of reported cases and outbreaks in the community is still substantially underestimated. We undertook a systematic review to determine the nature, scope and scale of community-based surveillance systems which capture information on norovirus disease. Methods: We searched MEDLINE, EMBASE and Scopus for studies published between 01 January 1995 and 31 December 2015, using terms relating to norovirus and surveillance. Publications were screened independently by two reviewers using exclusion criteria. Data extraction from included papers was performed using a standardized data extraction form. Outcomes were descriptions of the methods reported in included papers, and any estimates of incidence rate of norovirus disease in each community, stratified by age. Results: After exclusions, we reviewed 45 papers of which 23 described surveillance studies and 19 included estimates of incidence. The estimates of incidence varied by outcome measure, type of laboratory test and study population. There were two estimates of norovirus hospitalisation; 0.72 and 1.04 per 1000 person-years. Estimates of norovirus disease ranged between 0.024 cases per 1000 person-years and 60 cases per 1000 person-years and estimates of all gastroenteritis varied between 49 and 1100 cases per 1000 person-years. Conclusions: Our systematic review found few papers describing community-based surveillance for norovirus disease. Standardised age-specific estimates of norovirus incidence would be valuable for calculating the true global burden of norovirus disease; robust community surveillance systems would be able to produce this information. Trial Registration: PROSPERO 2016: CRD42016048659.

Publication metadata

Author(s): Inns T, Harris J, Vivancos R, Iturriza-Gomara M, O'Brien S

Publication type: Article

Publication status: Published

Journal: BMC Infectious Diseases

Year: 2017

Volume: 17

Issue: 1

Online publication date: 29/09/2017

Acceptance date: 22/09/2017

Date deposited: 22/08/2019

ISSN (electronic): 1471-2334

Publisher: BioMed Central Ltd.


DOI: 10.1186/s12879-017-2758-1

PubMed id: 28962598


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