Browse by author
Lookup NU author(s): Professor Sarah O'Brien
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
© 2015 Crown copyright 2015.Background: In July 2013, a rotavirus vaccination program for 2- to 3-month-olds was introduced in the United Kingdom. We present an initial impact analysis of this new vaccine program using national syndromic surveillance systems. Methods: General practitioner (GP) in-hours, GP out-of-hours, and emergency department (ED) syndromic surveillance systems were used to monitor GP consultations and ED visits for gastroenteritis, diarrhea, and vomiting. Data were stratified by age group and compared between pre- and postvaccine-year rotavirus seasons. Incidence rate ratios (IRRs) and percentage ratios were calculated for GP in-hours consultations and GP out-of-hours and ED data, respectively. Results: There was a significant reduction in gastroenteritis, diarrhea, and vomiting GP in-hours consultations in children aged 0-4 years when comparing the rotavirus season in the pre- and postvaccine years (P <. 001 for all indicators). IRRs illustrated a 26%-33% and 23%-31% decrease in gastroenteritis incidence in the <1 and 1-4 years age groups, respectively, across the syndromic surveillance systems. There was also an 8% decrease recorded in the 5-14 years age group in the GP in-hours and ED systems. Conclusions: Syndromic surveillance revealed a marked decline in gastroenteritis, coinciding with the introduction of the new rotavirus vaccine program in England. The largest reduction in disease was observed in infants, although some impact was also demonstrated in children aged 1-4 and 5-14 years, suggesting possible herd protection in older age groups. This study was limited to the first postvaccine year, and further analysis is required to assess the longer-term impact of the vaccine.
Author(s): Bawa Z, Elliot AJ, Morbey RA, Ladhani S, Cunliffe NA, O'Brien SJ, Regan M, Smith GE, Weinstein RA
Publication type: Article
Publication status: Published
Journal: Clinical Infectious Diseases
Year: 2015
Volume: 61
Issue: 1
Pages: 77-85
Online publication date: 31/03/2015
Acceptance date: 21/03/2015
ISSN (print): 1058-4838
ISSN (electronic): 1537-6591
Publisher: Oxford University Press
URL: https://doi.org/10.1093/cid/civ264
DOI: 10.1093/cid/civ264
PubMed id: 25828997
Altmetrics provided by Altmetric