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Language in schizophrenia and aphasia: the relationship with non-verbal cognition and thought disorder

Lookup NU author(s): Beth Little, Dr Peter Gallagher, Maggie Douglas, Helen Spencer, Dr Derya Cokal, Dr Felicity Deamer, Professor Douglas Turkington, Emeritus Professor Nicol Ferrier, Dr Stuart Watson

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This is the final published version of an article that has been published in its final definitive form by Taylor and Francis, 2019.

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Abstract

Objective: To determine the relationship between language abnormalities and broader cognitive impairment and thought disorder by examining language and cognition in schizophrenia and aphasia (a primary language disorder). Methods: Cognitive and linguistic profiles were measured with a battery of standardised tests, and compared in a clinical population of n=50 (n=30 with schizophrenia and n=20 with aphasia) and n=61 non-clinical comparisons (n=45 healthy controls and n=16 non-affected first-degree relatives of patients with schizophrenia). Results: Both clinical groups showed linguistic deficits. Verbal impairment was more severe in participants with aphasia, whereas non-verbal performance was more affected in participants with schizophrenia. In schizophrenia, but not in aphasia, verbal and non-verbal performance were associated. Formal thought disorder was associated with impairment in executive function and in grammatical, but not naming, tasks. Conclusion: While patients with schizophrenia and aphasia showed language impairments, the nature and cognitive basis of these impairments may be different; language performance disassociates from broader cognitive functioning in aphasia but may be an intrinsic expression of a broader cognitive impairment in schizophrenia. Thought disorder may represent a core malfunction of grammatical processing. Results suggests that communicative ability may be a valid target in cognitive remediation strategies in schizophrenia.


Publication metadata

Author(s): Little B, Gallagher P, Zimmerer V, Varley R, Douglas M, Spencer H, Çokal D, Deamer F, Turkington D, Ferrier IN, Hinzen W, Watson S

Publication type: Article

Publication status: Published

Journal: Cognitive Neuropsychiatry

Year: 2019

Volume: 24

Issue: 6

Pages: 389-405

Online publication date: 25/09/2019

Acceptance date: 04/09/2019

Date deposited: 10/09/2019

ISSN (print): 1354-6805

ISSN (electronic): 1464-0619

Publisher: Taylor and Francis

URL: https://doi.org/10.1080/13546805.2019.1668758

DOI: 10.1080/13546805.2019.1668758


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