Toggle Main Menu Toggle Search

Open Access padlockePrints

The role of the preterm intestinal microbiome in sepsis and necrotising enterocolitis

Lookup NU author(s): Andrea Masi, Dr Christopher StewartORCiD



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


© 2019. Late-onset sepsis (LOS) and necrotising enterocolitis (NEC) account for the highest number of deaths in premature infants and often cause severe morbidity in survivors. NEC is an inflammatory mediated condition, but its pathophysiology remains poorly understood. There is increasing evidence that in LOS the causative organism most often translocates from the gut. No causative microorganism has been consistently associated with either LOS or NEC, but an aberrant gut microbiome development could play a pivotal role. A low bacterial diversity and a delay in anaerobic bacteria colonization may predispose preterm infants to disease development. Conversely, a predominance of Bifidobacterium species and breast milk feeding might help to prevent disease onset. With numerous studies reporting conflicting results, further research is needed to better understand the role of microorganisms and type of feeding in the health status of preterm infants.

Publication metadata

Author(s): Masi AC, Stewart CJ

Publication type: Article

Publication status: Published

Journal: Early Human Development

Year: 2019

Online publication date: 31/08/2019

Acceptance date: 02/04/2018

Date deposited: 20/10/2019

ISSN (print): 0378-3782

ISSN (electronic): 1872-6232

Publisher: Elsevier Ireland Ltd


DOI: 10.1016/j.earlhumdev.2019.104854


Altmetrics provided by Altmetric