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Lookup NU author(s): Andrea Masi,
Dr Christopher Stewart
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
© 2019. Late-onset sepsis (LOS) and necrotising enterocolitis (NEC) account for the highest number of deaths in premature infants and often cause severe morbidity in survivors. NEC is an inflammatory mediated condition, but its pathophysiology remains poorly understood. There is increasing evidence that in LOS the causative organism most often translocates from the gut. No causative microorganism has been consistently associated with either LOS or NEC, but an aberrant gut microbiome development could play a pivotal role. A low bacterial diversity and a delay in anaerobic bacteria colonization may predispose preterm infants to disease development. Conversely, a predominance of Bifidobacterium species and breast milk feeding might help to prevent disease onset. With numerous studies reporting conflicting results, further research is needed to better understand the role of microorganisms and type of feeding in the health status of preterm infants.
Author(s): Masi AC, Stewart CJ
Publication type: Article
Publication status: Published
Journal: Early Human Development
Online publication date: 31/08/2019
Acceptance date: 02/04/2018
Date deposited: 20/10/2019
ISSN (print): 0378-3782
ISSN (electronic): 1872-6232
Publisher: Elsevier Ireland Ltd
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