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Oral Mucosal Injury Caused by Targeted Cancer Therapies

Lookup NU author(s): Professor Marco Carrozzo


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© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please email: cancer therapies have fundamentally transformed the treatment of many types of cancers over the past decade, including breast, colorectal, lung, and pancreatic cancers, as well as lymphoma, leukemia, and multiple myeloma. The unique mechanisms of action of these agents have resulted in many patients experiencing enhanced tumor response together with a reduced adverse event profile as well. Toxicities do continue to occur, however, and in selected cases can be clinically challenging to manage. Of particular importance in the context of this monograph is that the pathobiology for oral mucosal lesions caused by targeted cancer therapies has only been preliminarily investigated. There is distinct need for novel basic, translational, and clinical research strategies to enhance design of preventive and therapeutic approaches for patients at risk for development of these lesions. The research modeling can be conceptually enhanced by extrapolating "lessons learned" from selected oral mucosal conditions in patients without cancer as well. This approach may permit determination of the extent to which pathobiology and clinical management are either similar to or uniquely distinct from oral mucosal lesions caused by targeted cancer therapies. Modeling associated with oral mucosal disease in non-oncology patients is thus presented in this context as well. This article addresses this emerging paradigm, with emphasis on current mechanistic modeling and clinical treatment. This approach is in turn designed to foster delineation of new research strategies, with the goal of enhancing cancer patient treatment in the future.

Publication metadata

Author(s): Carrozzo M, Eriksen JG, Bensadoun R-J, Boers-Doets CB, Lalla RV, Peterson DE

Publication type: Article

Publication status: Published

Journal: Journal of the National Cancer Institute. Monographs

Year: 2019

Volume: 2019

Issue: 53

Print publication date: 19/08/2019

Online publication date: 19/08/2019

Acceptance date: 01/05/2019

ISSN (print): 1052-6773

ISSN (electronic): 1745-6614

Publisher: Oxford University Press


DOI: 10.1093/jncimonographs/lgz012

PubMed id: 31425602


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