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Assessing the safety of nanomedicines: A mini review

Lookup NU author(s): Professor Anne Dickinson, Dr Shaheda Ahmed

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Abstract

© 2019, Mary Ann Liebert, Inc., publishers.Over the past decade, there has been a significant increase in preclinical development and clinical use of approved nanomedicines. The nanomedicinal field represents a wide variety of products including early diagnostics such as in vivo imaging, medicinal devices, and innovative therapeutics. Nanomedicines exhibit unique physiochemical properties compared with their nonnanoformulated counterparts; however, clinical reports of moderate-to-severe allergic, anaphylaxis, and hypersensitivity reactions raise major concerns with regard to nanomedicine immunotoxicity. This review summarizes some of the main applications of nanomedicines, safety, and immunotoxicity implications and current testing strategies.

Publication metadata

Author(s): Dickinson AM, Godden JM, Lanovyk K, Ahmed SS

Publication type: Review

Publication status: Published

Journal: Applied In Vitro Toxicology

Year: 2019

Volume: 5

Issue: 3

Pages: 114-122

Online publication date: 17/09/2019

Acceptance date: 02/04/2016

ISSN (print): 2332-1512

ISSN (electronic): 2332-1539

Publisher: Mary Ann Liebert Inc.

URL: https://doi.org/10.1089/aivt.2019.0009

DOI: 10.1089/aivt.2019.0009

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