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Warburg and Krebs and related effects in cancer

Lookup NU author(s): Judith Unterlass, Professor Nicola CurtinORCiD

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Abstract

Warburg and coworkers' observation of altered glucose metabolism in tumours has been neglected for several decades, which, in part, was because of an initial misinterpretation of the basis of their finding. Following the realisation that genetic alterations are often linked to metabolism, and that the tumour micro-environment imposes different demands on cancer cells, has led to a reinvestigation of cancer metabolism in recent years. Increasing our understanding of the drivers and consequences of the Warburg effect in cancer and beyond will help to identify new therapeutic strategies as well as to identify new prognostic and therapeutic biomarkers. Here we discuss the initial findings of Warburg and coworkers regarding cancer cell glucose metabolism, how these studies came into focus again in recent years following the discovery of metabolic oncogenes, and the therapeutic potential that lies within targeting the altered metabolic phenotype in cancer. In addition, another essential nutrient in cancer metabolism, glutamine, will be discussed.

Publication metadata

Author(s): Unterlass JE, Curtin NJ

Publication type: Article

Publication status: Published

Journal: Expert Reviews in Molecular Medicine

Year: 2019

Volume: 21

Online publication date: 27/09/2019

Acceptance date: 28/05/2019

ISSN (electronic): 1462-3994

Publisher: Cambridge University Press

URL: https://doi.org/10.1017/erm.2019.4

DOI: 10.1017/erm.2019.4

PubMed id: 31558177

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