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Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor

Lookup NU author(s): Professor Akane Kawamura

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This is the authors' accepted manuscript of an article that has been published in its final definitive form by Royal Society of Chemistry, 2017.

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Abstract

© The Royal Society of Chemistry. Chemical tools that recognise post-translational modifications have promising applications in biochemistry and in therapy. We report a simple carboxycalixarene that selectively binds molecules containing di/trimethylammonium moieties in isolation, in cell lysates and when incorporated in histone peptides. Our findings reveal the potential of using carboxycalixarene-based receptors to study epigenetic regulation.

Publication metadata

Author(s): Hanauer T, Hopkinson RJ, Patel K, Li Y, Correddu D, Kawamura A, Sarojini V, Leung IKH, Gruber T

Publication type: Article

Publication status: Published

Journal: Organic and Biomolecular Chemistry

Year: 2017

Volume: 15

Issue: 5

Pages: 1100-1105

Print publication date: 07/02/2017

Online publication date: 04/01/2017

Acceptance date: 03/01/2017

Date deposited: 14/10/2019

ISSN (print): 1477-0520

ISSN (electronic): 1477-0539

Publisher: Royal Society of Chemistry

URL: https://doi.org/10.1039/c6ob02616h

DOI: 10.1039/c6ob02616h

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