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Lookup NU author(s): Dr Tom McAllisterORCiD,
Professor Akane Kawamura
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© 2015 American Chemical Society. There is increasing interest in targeting histone N-methyl-lysine demethylases (KDMs) with small molecules both for the generation of probes for target exploration and for therapeutic purposes. Here we update on previous reviews on the inhibition of the lysine-specific demethylases (LSDs or KDM1s) and JmjC families of N-methyl-lysine demethylases (JmjC KDMs, KDM2-7), focusing on the academic and patent literature from 2014 to date. We also highlight recent biochemical, biological, and structural studies which are relevant to KDM inhibitor development.
Author(s): McAllister TE, England KS, Hopkinson RJ, Brennan PE, Kawamura A, Schofield CJ
Publication type: Review
Publication status: Published
Journal: Journal of Medicinal Chemistry
Print publication date: 25/02/2016
Online publication date: 28/12/2015
Acceptance date: 10/11/2015
ISSN (print): 0022-2623
ISSN (electronic): 1520-4804
Publisher: American Chemical Society
PubMed id: 26710088