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Epigenetic regulation by histone demethylases in hypoxia

Lookup NU author(s): Professor Akane Kawamura



This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).


© 2015 A Kawamura.The response to hypoxia is primarily mediated by the hypoxia-inducible transcription factor (HIF). Levels of HIF are regulated by the oxygen-sensing HIF hydroxylases, members of the 2-oxoglutarate (2OG) dependent oxygenase family. JmjC-domain containing histone lysine demethylases (JmjC-KDMs), also members of the 2OG oxygenase family, are key epigenetic regulators that modulate the methylation levels of histone tails. Kinetic studies of the JmjC-KDMs indicate they could also act in an oxygen-sensitive manner. This may have important implications for epigenetic regulation in hypoxia. In this review we examine evidence that the levels and activity of JmjC-KDMs are sensitive to oxygen availability, and consider how this may influence their roles in early development and hypoxic disease states including cancer and cardiovascular disease.

Publication metadata

Author(s): Hancock RL, Dunne K, Walport LJ, Flashman E, Kawamura A

Publication type: Review

Publication status: Published

Journal: Epigenomics

Year: 2015

Volume: 7

Issue: 5

Pages: 791-811

Print publication date: 01/08/2015

Online publication date: 02/04/2015

Acceptance date: 01/01/1900

ISSN (print): 1750-1911

ISSN (electronic): 1750-192X

Publisher: Future Medicine Ltd.


DOI: 10.2217/epi.15.24

PubMed id: 25832587