Toggle Main Menu Toggle Search

Open Access padlockePrints

Systematic review of cognitive deficits in adult mitochondrial disease

Lookup NU author(s): Dr Heather Moore, Dr Alasdair Blain, Professor Doug Turnbull, Dr Grainne Gorman

Downloads


Licence

This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

The profile and trajectory of cognitive impairment in mitochondrial disease are poorly defined. This systematic review sought to evaluate the current literature on cognition in mitochondrial disease, and to determine future research directions. A systematic review was conducted, employing PubMed, Medline, Psycinfo, Embase and Web of Science, and 360-degree citation methods. English language papers on adult patients were included. The literature search yielded 2421 articles, of which 167 met inclusion criteria. Case reports and reviews of medical reports of patients yielded broad diagnoses of dementia, cognitive impairment and cognitive decline. In contrast, systematic investigations of cognitive functioning using detailed cognitive batteries identified focal cognitive rather than global deficits. Results were variable, but included visuospatial functioning, memory, attention, processing speed and executive functions. Conclusions from studies have been hampered by small sample sizes, variation in genotype and the breadth and depth of assessments undertaken. Comprehensive cognitive research with concurrent functional neuroimaging and physical correlates of mitochondrial disease in larger samples of well-characterized patients may discern the aetiology and progression of cognitive deficits. These data provide insights into the pattern and trajectory of cognitive impairments, which are invaluable for clinical monitoring, health planning and clinical trial readiness.


Publication metadata

Author(s): Moore HL, Blain AP, Turnbull DM, Gorman GS

Publication type: Review

Publication status: Published

Journal: European Journal of Neurology

Year: 2019

Pages: ePub ahead of print

Online publication date: 25/08/2019

Acceptance date: 21/08/2019

ISSN (print): 1351-5101

ISSN (electronic): 1468-1331

URL: https://doi.org/10.1111/ene.14068

DOI: 10.1111/ene.14068


Actions

Find at Newcastle University icon    Link to this publication


Share