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Cardiac 123I-MIBG normal uptake values are population-specific: Results from a cohort of controls over 60 years of age

Lookup NU author(s): Gemma Roberts, Dr James LloydORCiD, Dr Joseph Kane, Dr Rory Durcan, Dr Sarah Lawley, Dr George Petrides, Professor John O'Brien, Professor Alan ThomasORCiD


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© 2019, American Society of Nuclear Cardiology. Purpose: Cardiac 123I-MIBG image interpretation is affected by population differences and technical factors. We recruited older adults without cognitive decline and compared their cardiac MIBG uptake with results from the literature. Methods: Phantom calibration confirmed that cardiac uptake results from Japan could be applied to our center. We recruited 31 controls, 17 individuals with dementia with Lewy bodies (DLB) and 15 with Alzheimer’s disease (AD). Images were acquired 20 minutes and four hours after injection using Siemens cameras with medium-energy low-penetration (MELP) collimators. Local normal heart-to-mediastinum (HMR) ratios were compared to Japanese results. Results: Siemens gamma cameras with MELP collimators should give HMRs very close to the calibrated values used in Japan. However, our cut-offs with controls were lower at 2.07 for early and 1.86 for delayed images. Applying our lower cut-off to the dementia patients may increase the specificity of cardiac MIBG imaging for DLB diagnosis in a UK population without reducing sensitivity. Conclusions: Our local HMR cut-off values are lower than in Japan, higher than in a large US study but similar to those found in another UK center. UK centers using other cameras and collimators may need to use different cut-offs to apply our results.

Publication metadata

Author(s): Roberts G, Lloyd JJ, Kane JPM, Durcan R, Lawley S, Howe K, Petrides GS, O'Brien JT, Thomas AJ

Publication type: Article

Publication status: Published

Journal: Journal of Nuclear Cardiology

Year: 2021

Volume: 28

Pages: 1692-1701

Print publication date: 01/08/2021

Online publication date: 16/09/2019

Acceptance date: 22/08/2019

ISSN (print): 1071-3581

ISSN (electronic): 1532-6551

Publisher: Springer New York LLC


DOI: 10.1007/s12350-019-01887-6

PubMed id: 31529384


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