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Pathology and natural history of organ fibrosis

Lookup NU author(s): Dr Joaquim Majo, Dr Dina Tiniakos



© 2019 Elsevier LtdHistopathological assessment of fibrosis focusing on morphological patterns provides important information for the management of patients with chronic diseases of the kidney, liver and the lung. This review summarizes key histopathological features of pulmonary, renal and hepatic fibrosis and discusses advances in the understanding of the pathogenesis of pulmonary fibrosis and pathogenetic insights with translational implications for renal fibrosis. The review also tackles new staging approaches based on liver fibrosis dynamics and evaluation of fibrosis regression, digital pathology and second harmonic generation microscopy methods for hepatic fibrosis assessment and critical appraisal of non-invasive tests for liver and renal fibrosis evaluation.

Publication metadata

Author(s): Majo J, Klinkhammer BM, Boor P, Tiniakos D

Publication type: Review

Publication status: Published

Journal: Current Opinion in Pharmacology

Year: 2019

Volume: 49

Pages: 82-89

Online publication date: 28/10/2019

Acceptance date: 02/04/2019

ISSN (print): 1471-4892

ISSN (electronic): 1471-4973

Publisher: Elsevier Ltd


DOI: 10.1016/j.coph.2019.09.009