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A candidate gene association study of bone mineral density in an Iranian population

Lookup NU author(s): Professor Dawn Teare



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2016 Dastgheib, Gartland, Tabei, Omrani and Teare. The genetic epidemiology of variation in bone mineral density (BMD) and osteoporosis is not well studied in Iranian populations and needs more research. We report a candidate gene association study of BMD variation in a healthy cross-sectional study of 501 males and females sampled from the Iranian Multi-Centre Osteoporosis Study, Shiraz, Iran. We selected to study the association with 21 single nucleotide polymorphisms (SNPs) located in the 7 candidate genes LRP5, RANK, RANKL, OPG, P2RX7, VDR, and ESR1. BMD was measured at the three sites L2-L4, neck of femur, and total hip. Association between BMD and each SNP was assessed using multiple linear regression assuming an allele dose (additive effect) on BMD (adjusted for age and sex). Statistically significant (at the unadjusted 5% level) associations were seen with seven SNPs in five of the candidate genes. Two SNPs showed statistically significant association with more than one BMD site. Significant association was seen between BMD at all the three sites with the VDR SNP rs731246 (L2-L4 p = 0.038; neck of femur p = 0.001; and total hip p < 0.001). The T allele was consistently associated with lower BMD than the C allele. Significant association was also seen for the P2RX7 SNP rs3751143, where the G allele was consistently associated with lower BMD than the T allele (L2-L4 p = 0.069; neck of femur p = 0.024; and total hip p = 0.045).

Publication metadata

Author(s): Dastgheib SA, Gartland A, Tabei SMB, Omrani GR, Teare MD

Publication type: Article

Publication status: Published

Journal: Frontiers in Endocrinology

Year: 2016

Volume: 7

Online publication date: 27/10/2016

Acceptance date: 13/10/2016

Date deposited: 12/11/2019

ISSN (electronic): 1664-2392

Publisher: Frontiers Research Foundation


DOI: 10.3389/fendo.2016.00141


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